||Physiological roles of orexin receptors on sleep/wakefulness regulation
Mieda, Michihiro ,
Orexin and Sleep: Molecular, Functional and Clinical Aspects
65 , 2015-09-22 , Springer International Publishing
Hypothalamic neuropeptides orexin-A and orexin-B play critical roles in the regulation of sleep/wakefulness, as well as in a variety of physiological functions including emotion, reward and energy homeostasis. The effects of orexin peptides are mediated by two receptors, orexin 1 (OX1R) and orexin 2 (OX2R) receptors. These receptors show differential expression patterns depending on brain regions and neuron types, suggesting their differential roles. Here, we review the current understanding of the physiological roles of each orexin receptor subtype, focusing on the regulation of sleep/wakefulness. © Springer International Publishing Switzerland 2015. All rights reserved.