||Differentiation of Donor-Derived Cells into Microglia after Umbilical Cord Blood Stem Cell Transplantation
Takahashi, Kazuya ,
Kakuda, Yumiko ,
Munemoto, Saori Yamazaki, Hirohito ,
Nozaki, IchiroYamada, Masahito
Journal of Neuropathology and Experimental Neurology
866 , 2015-09-29 , American Association of Neuropathologists / Lippincott Williams and Wilkins
Recent studies have indicated that microglia originate from immature progenitors in the yolk sac. After birth, microglial populations are maintained under normal conditions via self-renewal without the need to recruit monocyte-derived microglial precursors. Peripheral cell invasion of the brain parenchyma can only occur with disruption of the blood-brain barrier. Here, we report an autopsy case of an umbilical cord blood transplant recipient in whom cells derived from the donor blood differentiated into ramified microglia in the recipient brain parenchyma. Although the blood-brain barrier and glia limitans seemed to prevent invasion of these donor-derived cells, most of the invading donor-derived ramified cells were maintained in the cerebral cortex. This result suggests that invasion of donor-derived cells occurs through the pial membrane. Copyright © 2015 by the American Association of Neuropathologists, Inc.