Thesis or Dissertation Molecular regulation and biological function of NRF3 (NFE2L3) in cancer cells
ガン サイボウ ニオケル テンシャ インシ NRF3(NFE2L3)ノ セイギョ キコウ ト キノウ

Chowdhury, A M Masudul Azad

I found multiple regulation of NRF3 activities promotes cell proliferation. My analyses reveal (1) under physiological conditions, NRF3 is rapidly degraded by the ER-associated degradation (ERAD) ubiquitin ligase HRD1 and valosin-containing protein (VCP) in the cytoplasm; (2) NRF3 is also degraded by β-TRCP, an adaptor for the Skp1-Cul1-F-box protein (SCF) ubiquitin ligase in the nucleus; (3) NRF3 mediates gene expression of the cell cycle regulator U2AF homology motif kinase 1 (UHMK1) for cell proliferation; (4) the nature of the activation mechanism of NRF3 is not the inhibition of its HRD1-VCP-mediated degradation. Collectively, this study provides us many insights into biological function of NRF3 in cancer cells.

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