Thesis or Dissertation Using a novel PV-Cre rat model to characterize pallidonigral cells and their terminations
PV-Cre ラット モデル オ モチイタ タンソウキュウ ガイセツ サイボウ ノ コクシツ ドーパミン サイボウ エノ ヨクセイセイ ニュウリョク ノ カイメイ

Oh, Yoon Mi  ,  オ, ユンミ  ,  呉, 胤美  ,  Oh, Yoon-Mi

The present study aimed to identify the characteristic projection pattern of parvalbumin (PV) neurons in the globus pallidus (GP) and examined whether these neurons target dopaminergic or GABAergic neurons in the substantia nigra (SN). Consequently, We found that 1) 57% of PV neurons co-expressed Lim-homeobox 6, 2) the PV-GP terminals were preferentially distributed in the ventral part of dorsal tier of SN pars compacta (SNc), 3) PV-GP neurons formed basket-like appositions with the somata in the SN, and 4) in vitro whole cell recording demonstrated that PV-GP neurons strongly inhibited dopamine neurons in the SNc via GABAA receptors.

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