Thesis or Dissertation Critical role of Ca2+ current facilitation in the short-term facilitation of Purkinje cell-Purkinje cell synapses
プリキンエ サイボウカン シナプス タンキ ソクツウ ゲンショウ ニオケル Ca デンリュウ ノ ヤクワリ

Díaz-Rojas, Françoise  ,  ディアス ロハス, フランスア

Short-term facilitation, a form of synaptic plasticity, takes place at GABAergic synapses between cerebellar Purkinje cells (PCs). We studied the mechanism of this short-term facilitation by directly patch-clamp recording from a PC axon terminal in cerebellar cultures. We show that the Ca2+ currents elicited by high-frequency action potentials were augmented depending on intracellular [Ca2+] on the terminal. The facilitation of synaptic transmission showed 4-5th power dependence on the Ca2+ current facilitation, and was abolished when the Ca2+ current facilitation was supressed. We conclude that short-term facilitation of Ca2+ currents predominantly mediates short-term facilitation at synapses between PCs.

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