学位論文 Critical role of Ca2+ current facilitation in the short-term facilitation of Purkinje cell : Purkinje cell synapses

Díaz-Rojas, Françoise  ,  ディアス ロハス, フランスア

2016-03-22
内容記述
Short-term facilitation, a form of synaptic plasticity, takes place at GABAergic synapses between cerebellar Purkinje cells (PCs). We studied the mechanism of this short-term facilitation by directly patch-clamp recording from a PC axon terminal in cerebellar cultures. We show that the Ca2+ currents elicited by high-frequency action potentials were augmented depending on intracellular [Ca2+] on the terminal. The facilitation of synaptic transmission showed 4-5th power dependence on the Ca2+ current facilitation, and was abolished when the Ca2+ current facilitation was supressed. We conclude that short-term facilitation of Ca2+ currents predominantly mediates short-term facilitation at synapses between PCs.
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https://doors.doshisha.ac.jp/duar/repository/ir/23058/k797.pdf

https://doors.doshisha.ac.jp/duar/repository/ir/23058/zk797.pdf

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