Journal Article Recent Progress in the Understanding of Angioimmunoblastic T-cell Lymphoma

Fujisawa, Manabu  ,  Chiba, Shigeru  ,  Sakata-Yanagimoto, Mamiko

57 ( 3 )  , pp.109 - 119 , 2017-12 , the Japanese Society of Lymphoreticular Tissue Research , 日本リンパ網内系学会
ISSN:1346-4280
NCID:AA11556796
Description
Angioimmunoblastic T-cell lymphoma (AITL) has been classified as a subtype of mature T-cell neoplasms. The recent revision of the WHO classification proposed a new category of nodal T-cell lymphoma with follicular helper T (TFH)-cell phenotype, which was classified into three diseases: AITL, follicular T-cell lymphoma, and nodal peripheral T-cell lymphoma with TFH phenotype. These lymphomas are defined by the expression of TFH-related antigens, CD279/PD-1, CD10, BCL6, CXCL13, ICOS, SAP, and CXCR5. Although recurrent mutations in TET2, IDH2, DNMT3A, RHOA, and CD28, as well as gene fusions, such as ITK-SYK and CTLA4-CD28, were not diagnostic criteria, they may be considered as novel criteria in the near future. Notably, premalignant mutations, tumor-specific mutations, and mutations specific to tumor-infiltrating B cells were identified in AITL. Thus, multi-step and multi-lineage genetic events may lead to the development of AITL.
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