Departmental Bulletin Paper げっ歯類における薬物・ギャンブル依存と意思決定プロセスの関係に関する研究の動向
Studies of the biological mechanisms underlying the relationship between drug- or gambledependences and decision-making processes in rodents: A review

高橋, 克匡  ,  一谷, 幸男  ,  山田, 一夫

55pp.1 - 7 , 2018-02-28 , Division of Physhology, Faculty of Human Sciences, University of Tsukuba , 筑波大学人間系心理学域
Dependence refers to the state of abnormally relying on or needing someone or something. Although the neural mechanisms of drug-dependence have been intensively studied, those of gambledependences are still unclear. Since "gambling disorder" was adopted within the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) as a mental disorder, researchers have been focusing on developing an effective treatment for the disorder. Deviant decision-making processes, such as risk preference or short-sighted thinking, are thought to be related to both drug- and gambledependences. Elucidating the biological mechanisms of deviant decision-making processes using the rat gambling task (rGT), based on the Iowa Gambling Task for humans, can undoubtedly provide novel approaches to the treatments of drug dependences and gamble disorder. In this paper, we focus on the relationships between drug- and gamble-dependences and decision-making processes and review recent studies that address the biological mechanisms underlying the deviant decision-making processes in rodents.

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