学術雑誌論文 Striatal adenosine A2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus

Yuan, Xiang-Shan  ,  Wang, Lu  ,  Dong, Hui  ,  Qu, Wei-Min  ,  Yang, Su-Rong  ,  Cherasse, Yoan  ,  Lazarus, Michael  ,  Schiffmann, Serge N  ,  d'Exaerde, Alban de Kerchove  ,  Li, Rui-Xi  ,  Huang, Zhi-Li

6p.e29055 , 2017-10 , eLife Sciences Publications, Ltd
ISSN:2050-084x
内容記述
Dysfunction of the striatum is frequently associated with sleep disturbances. However, its role in sleep-wake regulation has been paid little attention even though the striatum densely expresses adenosine A2A receptors (A2ARs), which are essential for adenosine-induced sleep. Here we showed that chemogenetic activation of A2AR neurons in specific subregions of the striatum induced a remarkable increase in non-rapid eye movement (NREM) sleep. Anatomical mapping and immunoelectron microscopy revealed that striatal A2AR neurons innervated the external globus pallidus (GPe) in a topographically organized manner and preferentially formed inhibitory synapses with GPe parvalbumin (PV) neurons. Moreover, lesions of GPe PV neurons abolished the sleep-promoting effect of striatal A2AR neurons. In addition, chemogenetic inhibition of striatal A2AR neurons led to a significant decrease of NREM sleep at active period, but not inactive period of mice. These findings reveal a prominent contribution of striatal A2AR neuron/GPe PV neuron circuit in sleep control.
本文を読む

https://tsukuba.repo.nii.ac.jp/?action=repository_action_common_download&item_id=44210&item_no=1&attribute_id=17&file_no=1

このアイテムのアクセス数:  回

その他の情報