学術雑誌論文 Dose-Dependent Effect of Sitagliptin on Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus Receiving Insulin Treatment: A Post Hoc Analysis

Mita, Tomoya  ,  Katakami, Naoto  ,  Shiraiwa, Toshihiko  ,  Yoshii, Hidenori  ,  Gosho, Masahiko  ,  Shimomura, Iichiro  ,  Watada, Hirotaka

8 ( 5 )  , pp.1135 - 1146 , 2017-10 , Springer
ISSN:1869-6953
内容記述
IntroductionDipeptidyl peptidase-4 (DPP-4) inhibitors reduce blood glucose in a dose-dependent manner, but the dose-dependent effect relationship between DPP-4 inhibitors and atherosclerosis has not been investigated.MethodsPatients with type 2 diabetes mellitus (T2DM) treated with insulin were randomized to the sitagliptin (n = 137) or conventional treatment group (n = 137). In the sitagliptin group, each investigator was allowed to adjust the sitagliptin dose to avoid hypoglycemia. In this post hoc analysis, subjects in the sitagliptin group were divided into two groups based on the average dose of sitagliptin during the study period: greater than or equal to median (higher sitagliptin dose group) or less than median (lower sitagliptin dose group).ResultsIn this study, subjects were divided into three groups: the conventional treatment group (n = 137), lower sitagliptin dose group (n = 42), and higher sitagliptin dose group (n = 95). The higher sitagliptin dose group had a significantly larger reduction in HbA1c (−0.62 ± 1.05%) than the conventional treatment group (−0.20 ± 0.91%, P = 0.007). Over 104 weeks, the higher sitagliptin dose significantly reduced the mean intima media thickness-common carotid artery (IMT-CCA) and left max-IMT-CCA relative to baseline. In addition, the higher sitagliptin dose significantly inhibited the progression in mean-IMT-CCA compared with conventional treatment. Multiple linear regression analysis showed that changes in mean-IMT-CCA and left max-IMT-CCA decreased with higher sitagliptin dose.ConclusionsAddition of sitagliptin to insulin therapy might attenuate the progression of atherosclerosis in patients with T2DM in a dose-dependent manner.
本文を読む

https://tsukuba.repo.nii.ac.jp/?action=repository_action_common_download&item_id=43705&item_no=1&attribute_id=17&file_no=1

このアイテムのアクセス数:  回

その他の情報