学術雑誌論文 Effectiveness of Plasmapheresis in a Patient with Anti-glomerular Basement Membrane Antibody Glomerulonephritis with Advanced Kidney Dysfunction

Usui, Toshiaki  ,  Kai, Hirayasu  ,  Noguchi, Kazuyuki  ,  Morito, Naoki  ,  Usui, Joichi  ,  Saito, Chie  ,  Uesugi, Noriko  ,  Nagata, Michio  ,  Yamagata, Kunihiro

56 ( 18 )  , pp.2475 - 2479 , 2017-09 , Japanese Society of Internal Medicine
ISSN:0918-2918
NII書誌ID(NCID):AA10827774
内容記述
Patients with anti-glomerular basement membrane antibody glomerulonephritis (anti-GBM GN) have severe kidney dysfunction, leading to end-stage renal disease. The effect of plasmapheresis and immunosuppressive treatment in patients with severe glomerular changes is controversial. A 62-year-old man was admitted with rapidly progressive glomerulonephritis and diagnosed with anti-GBM GN. He required hemodialysis. All glomeruli in the kidney biopsy specimen had cellular crescents without fibrotic changes, suggesting reversible damage. He was treated with plasmapheresis until the anti-glomerular basement membrane antibodies disappeared. His kidney function recovered, and dialysis was able to be discontinued. Frequent plasmapheresis in patients with dialysis-dependent anti-GBM GN may improve the kidney prognosis.
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