学術雑誌論文 Ovarian ecdysteroid biosynthesis and female germline stem cells

AMEKU, Tomotsune  ,  YOSHINARI, Yuto  ,  FUKUDA, Ruriko  ,  NIWA, Ryusuke

11 ( 3 )  , pp.185 - 193 , 2017-07 , Taylor & Francis
ISSN:1933-6934
NII書誌ID(NCID):AA12630136
内容記述
The germline stem cells (GSCs) are critical for gametogenesis throughout the adult life. Stem cell identity is maintained by local signals from a specialized microenvironment called the niche. However, it is unclear how systemic signals regulate stem cell activity in response to environmental cues. In our previous article, we reported that mating stimulates GSC proliferation in female Drosophila. The mating-induced GSC proliferation is mediated by ovarian ecdysteroids, whose biosynthesis is positively controlled by Sex peptide signaling. Here, we characterized the post-eclosion and post-mating expression pattern of the genes encoding the ecdysteroidogenic enzymes in the ovary. We further investigated the biosynthetic functions of the ovarian ecdysteroid in GSC maintenance in the mated females. We also briefly discuss the regulation of the ecdysteroidogenic enzyme-encoding genes and the subsequent ecdysteroid biosynthesis in the ovary of the adult Drosophila.
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