Journal Article Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis

Pierini, Antonio  ,  Nishikii, Hidekazu  ,  Baker, Jeanette  ,  Kimura, Takaharu  ,  Kwon, Hye-Sook  ,  Pan, Yuqiong  ,  Chen, Yan  ,  Alvarez, Maite  ,  Strober, William  ,  Velardi, Andrea  ,  Shizuru, Judith A.  ,  Wu, Joy Y.  ,  Chiba, Shigeru  ,  Negrin, Robert S.

8p.15068 , 2017-05 , Nature Publishing Group
Foxp3+ regulatory T cells (Treg cells) modulate the immune system and maintain self-tolerance, but whether they affect haematopoiesis or haematopoietic stem cell (HSC)-mediated reconstitution after transplantation is unclear. Here we show that B-cell lymphopoiesis is impaired in Treg-depleted mice, yet this reduced B-cell lymphopoiesis is rescued by adoptive transfer of affected HSCs or bone marrow cells into Treg-competent recipients. B-cell reconstitution is abrogated in both syngeneic and allogeneic transplantation using Treg-depleted mice as recipients. Treg cells can control physiological IL-7 production that is indispensable for normal B-cell lymphopoiesis and is mainly sustained by a subpopulation of ICAM1+ perivascular stromal cells. Our study demonstrates that Treg cells are important for B-cell differentiation from HSCs by maintaining immunological homoeostasis in the bone marrow microenvironment, both in physiological conditions and after bone marrow transplantation.

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