Journal Article Conserved role of Ovo in germline development in mouse and Drosophila

Hayashi, Makoto  ,  Shinozuka, Yuko  ,  Shigenobu, Shuji  ,  Sato, Masanao  ,  Sugimoto, Michihiko  ,  Ito, Seiji  ,  Abe, Kuniya  ,  Kobayashi, Satoru

7p.40056 , 2017-01 , Nature Publishing Group
ISSN:2045-2322
Description
Ovo, which encodes a transcription factor with Zn-finger domains, is evolutionarily conserved among animals. In Drosophila, in addition to its zygotic function for egg production, maternal ovo activity is required in primordial germ cells (PGCs) for expression of germline genes such as vasa and nanos. In this study, we found that maternal Ovo accumulates in PGC nuclei during embryogenesis. In these cells, ovo serves a dual function: activation of genes expressed predominantly in PGCs, and conversely suppression of somatic genes. Reduction of ovo activity in PGCs makes them unable to develop normally into germ cells of both sexes. In mice, knockout of the ovo ortholog, Ovol2, which is expressed in PGCs, decreases the number of PGCs during early embryogenesis. These data strongly suggest that ovo acts as part of an evolutionarily conserved mechanism that regulates germline development in animals.
Full-Text

https://tsukuba.repo.nii.ac.jp/?action=repository_action_common_download&item_id=40265&item_no=1&attribute_id=17&file_no=1

Number of accesses :  

Other information