Journal Article First total synthesis of haplacutine C

Kutsumura, Noriki  ,  Numata, Keisuke  ,  Saito, Takao

57 ( 50 )  , pp.5581 - 5583 , 2016-12 , Elsevier Ltd.
ISSN:00404039
NCID:AA00861801
Description
A total synthesis of haplacutine C has been achieved. The synthetic key features were the intramolecular aldol condensation for construction of the 4-quinolinone skeleton and the Stille coupling for elongation of the dienol side chain. In addition, the 4-O-protected-quinolines were also utilized as the synthetic equivalents of 4-quinolinone at the stage of side chain transformation.
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