||First total synthesis of haplacutine C
Kutsumura, Noriki ,
Numata, KeisukeSaito, Takao
5583 , 2016-12 , Elsevier Ltd.
A total synthesis of haplacutine C has been achieved. The synthetic key features were the intramolecular aldol condensation for construction of the 4-quinolinone skeleton and the Stille coupling for elongation of the dienol side chain. In addition, the 4-O-protected-quinolines were also utilized as the synthetic equivalents of 4-quinolinone at the stage of side chain transformation.