Journal Article Mediastinal lymph node metastasis of renal cell carcinoma: A case report

Miyazaki, Kunihiko  ,  Sato, Shinya  ,  Kodama, Takahide  ,  Kurishima, Koichi  ,  Satoh, Hiroaki  ,  Hizawa, Nobuyuki

11 ( 2 )  , pp.1600 - 1602 , 2016-02 , Spandidos Publications
Renal cell carcinoma (RCC) may metastasize to mediastinal lymph nodes without any abdominal lymph node involvement. The present study describes an autopsy‑proven case of RCC presenting with a large mediastinal mass; the case had been previously misdiagnosed as small cell lung carcinoma due to imaging analysis results, an elevated serum level of neuron‑specific enolase and the presence of small atypical cells with a high nuclear/cytoplasmic ratio. Despite RCC occurrence being rare, it should be considered in the differential diagnosis, particularly when a mass located in the kidneys presents with metastases to the mediastinal lymph nodes, even if there is no involvement of the abdominal lymph nodes and the primary lesion is of a small size.

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