Journal Article Total Synthesis of Mycalolides A and B through Olefin Metathesis

Kita, Masaki  ,  Oka, Hirotaka  ,  Usui, Akihiro  ,  Ishitsuka, Tomoya  ,  Mogi, Yuzo  ,  Watanabe, Hidekazu  ,  Tsunoda, Masaki  ,  Kigoshi, Hideo

54 ( 47 )  , pp.14174 - 14178 , 2015-11 , Wiley-VCH
An asymmetric total synthesis of the trisoxazole marine macrolides mycalolides A and B is described. This synthesis involves the convergent assembly of highly functionalized C1–C19 trisoxazole and C20–C35 side-chain segments through the use of olefin metathesis and esterification as well as Julia–Kocienski olefination and enamide formation as key steps.

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