Journal Article Preparation of monodisperse aqueous microspheres containing high concentration of l-ascorbic acid by microchannel emulsification

Khalid, Nauman  ,  Kobayashi, Isao  ,  Neves, Marcos A.  ,  Uemura, Kunihiko  ,  Nakajima, Mitsutoshi  ,  Nabetani, Hiroshi

32 ( 6 )  , pp.570 - 577 , 2015-07 , Taylor & Francis
Monodisperse aqueous microspheres containing high concentrations of l-ascorbic acid with different concentrations of sodium alginate (Na-ALG) and magnesium sulfate (MgSO4) were prepared by using microchannel emulsification (MCE). The continuous phase was water-saturated decane containing a 5% (w/w) hydrophobic emulsifier. The flow rate of the continuous phase was maintained at 10 mL h−1, whereas the pressure applied to the disperse phase was varied between 3 and 25 kPa. The disperse phase optimized for successfully generating aqueous microspheres included 2% (w/w) Na-ALG and 1% (w/w) MgSO4. At a higher MgSO4 concentration, the generated microspheres resulted in coalescence and subsequent bursting. At a lower MgSO4 concentration, unstable and polydisperse microspheres were obtained. The aqueous microspheres generated from the MCs under optimized conditions had a mean particle diameter (dav) of 14–16 µm and a coefficient of variation (CV) of less than 8% at the disperse phase pressures of 5–15 kPa.

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