Journal Article Severe airflow obstruction in a patient with ulcerative colitis and toxic epidermal necrolysis: A case report

Taguchi, Shijima  ,  Furuta, Junichi  ,  Ohara, Gen  ,  Kagohashi, Katsunori  ,  Satoh, Hiroaki

9 ( 5 )  , pp.1944 - 1946 , 2015-05 , Spandidos Publications
Bronchiolitis is a rare condition mainly affecting the intralobular conducting and transitional small airways. The present study describes a case of severe airflow limitation in a patient with ulcerative colitis who developed toxic epidermal necrolysis following mesalazine therapy. Forced expiratory volume in one second was decreased and a flow‑volume curve showed airflow limitation, but the single‑breath diffusing capacity of the lung for carbon monoxide (DLCO) and DLCO divided by alveolar volume (DLCO/VA) were not decreased. This rare clinical condition should be considered as a differential diagnosis for subjects presenting with sub‑acutely developed airflow obstruction if the findings in chest computed tomography scans demonstrate hyperinflation but few low‑attenuation areas. Relatively well‑preserved DLCO and DLCO/VA provide a clue to establishing the correct diagnosis.

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