||Severe airflow obstruction in a patient with ulcerative colitis and toxic epidermal necrolysis: A case report
Taguchi, Shijima ,
Furuta, Junichi ,
Ohara, Gen ,
Kagohashi, KatsunoriSatoh, Hiroaki
Experimental and therapeutic medicine
1946 , 2015-05 , Spandidos Publications
Bronchiolitis is a rare condition mainly affecting the intralobular conducting and transitional small airways. The present study describes a case of severe airflow limitation in a patient with ulcerative colitis who developed toxic epidermal necrolysis following mesalazine therapy. Forced expiratory volume in one second was decreased and a flow‑volume curve showed airflow limitation, but the single‑breath diffusing capacity of the lung for carbon monoxide (DLCO) and DLCO divided by alveolar volume (DLCO/VA) were not decreased. This rare clinical condition should be considered as a differential diagnosis for subjects presenting with sub‑acutely developed airflow obstruction if the findings in chest computed tomography scans demonstrate hyperinflation but few low‑attenuation areas. Relatively well‑preserved DLCO and DLCO/VA provide a clue to establishing the correct diagnosis.