Journal Article 高線量率イリジウム線源を用いた組織内小線源治療による舌癌治療の検討
Long-term outcomes of interstitial brachytherapy with the high dose rate iridium source for tongue cancer treatment
コウ センリョウリツ イリジウム センゲン オ モチイタ ソシキナイ ショウ センゲン チリョウ ニヨル ゼツガン チリョウ ノ ケントウ

堀永, 大樹  ,  真野, 隆充  ,  内田, 堅一郎  ,  原田, 耕志  ,  梅田, 浩嗣  ,  岡藤, 正樹  ,  三島, 克章  ,  上山, 吉哉

66 ( 4 )  , pp.211 - 217 , 2017-10-06 , 山口大学医学会
Fourteen patients with tongue squamous cell carcinoma were treated with high-dose-rate interstitial brachytherapy. The patients consisted of nine males and five females aged from 40 to 88 years(median age, 71.0 years).As an initial treatment, external radiotherapy was combined for three patients, and intra-arterial chemotherapy was combined for eleven patients.Five-year local control rates were 92.9%. Local recurrence and delayed neck lymph nodes metastasis were detected in two cases(14.3%)and three cases(21.4%)respectively, but all patients lived in non-cancer bearing now, except the one who died from the other illness. The major adverse events were oral mucositis, xerostomia and bone exposure with ulcer. Especially oral mucositis was found in all case, and bone exposure and xerostomia often occurred as late complication. Our date suggested that high-dose-rate brachytherapy for tongue cancer patient may be an effective and an acceptable therapy as a functional preservation therapy against oral cancer. However, this therapy may have a risk of occurrence of radiation osteonecrosis. Thus, we must follow the patient closely.

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