Departmental Bulletin Paper Relationship between the myocardial oxidative stress and cardiac sympathetic hyperactivity in patients with takotsubo cardiomyopathy

Oda, Seiko  ,  Kobayashi, Shigeki  ,  Nanno, Takuma  ,  Ishiguchi, Hironori  ,  Myoren, Takeki  ,  Murakami, Wakako  ,  Mochizuki, Mamoru  ,  Oda, Tetsuro  ,  Okuda, Shinichi  ,  Yamada, Jutaro  ,  Okamura, Takayuki  ,  Matsuzaki, Masunori  ,  Yano, Masafumi

63 ( 1-2 )  , pp.5 - 16 , 2016 , Yamaguchi University School of Medicine
ISSN:0513-1812
NCID:AA00594272
Description
We investigated the relationship between myocardial oxidative stress and cardiac sympathetic hyperactivity in patients with takotsubo cardiomyopathy (TC) compared with acute anteroseptal myocardial infarction (AMI). Methods: In 10 TC patients and 10 AMI patients, electrocardiogram, echocardiography, cardiac catheterization were conducted, and plasma catecholamines and urinary (U) 8-hydroxy-2’-deoxyguanosine (8-OHdG) as a marker of oxidative DNA damage were taken for one week from onset. Results: On admission, the coronary sinus (CS) had significantly higher norepinephrine (NE) and 8-OHdG levels than the aortic root (Ao) and peripheral blood vessels. Circulating catecholamines in TC patients tended to be higher than those in AMI patients; especially, peripheral plasma NE levels (day 1) in patients with TC were significantly higher than those in patients with AMI. TC patients had elevated U-8-OHdG in parallel with elevated NE, whereas, AMI patients had U-8-OHdG level that decreased to almost normal range within one week. On day 1, in patients with TC, serum 8-OHdG differences (CS vs Ao) and U-8-OHdG increased proportionally with the wall-motion score as an index of LV dysfunction, whereas serum NE (CS vs Ao) did not. Conclusion: Myocardial oxidative stress induced by cardiac sympathetic hyperactivity may play a critical role in transient LV dysfunction in TC.
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http://petit.lib.yamaguchi-u.ac.jp/G0000006y2j2/file/26486/20160923132405/A050063000102.pdf

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