Journal Article 同一腺管上皮に腺扁平上皮癌成分への移行を伴う多形細胞型退形成性膵管癌の1例
A case of anaplastic ductal carcinoma with adenosquamous carcinoma of the pancreas
ドウイツ センカン ジョウヒ ニ センヘンペイ ジョウヒガン セイブン エノ イコウ オ トモナウ タケイ サイボウガタ タイケイセイセイ スイカンガン ノ 1レイ

上杉, 尚正  ,  池下, 貴広  ,  井上, 貴之  ,  弘中, 秀治  ,  神保, 充孝  ,  小林, 俊郎  ,  斎藤, 聰  ,  高橋, 剛  ,  郷良, 秀典  ,  田中, 慎介

65 ( 3 )  , pp.143 - 148 , 2016-08-01 , 山口大学医学会
A 73-year-old woman was admitted to our hospital for further examination of abdominal pain. An abdominal CT showed an irregularly shaped tumor with a diameter of 70 mm in the tail of the pancreas. We diagnosed the case as pancreatic tail cancer and an operation was performed. At laparotomy, the tumor showed general expanding growth and direct invasion through the adjust organs. We performed distal pancreatectomy and splenectomy with total gastrectomy, partial resection of jejunum, partial transverse colectomy, and left adrenalectomy. The resected specimen showed an elastic hard tumor with sarcomatous change growing towards outside of the pancreas. The cut surface was yellow-white and showing partial necrotic change. The histopathologilcal diagnosis was pleomorphic cell type anaplastic ductal carcinoma with adenosquamous carcinoma. Abdominal CT scan performed four months after the operation revealed local recurrence and peritoneal dissemination. The patient died of cancer five months after resection. The tumor was diagnosed as coexist two histological types of cancer cells with high proliferating potential, so it is very difficult to cure with rapid progression. We hope to establish a more definitive treatment for this disease through ongoing encounters with patients.

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