学術雑誌論文 Splicing factors control C. elegans behavioural learning in a single neuron by producing DAF-2c receptor

Tomioka, Masahiro  ,  Naito, Yasuki  ,  Kuroyanagi, Hidehito  ,  Iino, Yuichi

7p.11645 , 2016-05-20 , Nature Publishing Group
ISSN:2041-1723
NII書誌ID(NCID):AA12645905
内容記述
Alternative splicing generates protein diversity essential for neuronal properties. However, the precise mechanisms underlying this process and its relevance to physiological and behavioural functions are poorly understood. To address these issues, we focused on a cassette exon of the Caenorhabditis elegans insulin receptor gene daf-2, whose proper variant expression in the taste receptor neuron ASER is critical for taste-avoidance learning. We show that inclusion of daf-2 exon 11.5 is restricted to specific neuron types, including ASER, and is controlled by a combinatorial action of evolutionarily conserved alternative splicing factors, RBFOX, CELF and PTB families of proteins. Mutations of these factors cause a learning defect, and this defect is relieved by DAF-2c (exon 11.5þ) isoform expression only in a single neuron ASER. Our results provide evidence that alternative splicing regulation of a single critical gene in a single critical neuron is essential for learning ability in an organism.
UTokyo Research掲載「飢餓の記憶の形成に必要な分子が作られるしくみ」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/production-of-a-molecule-for-memory-of-salt-concentration.html
UTokyo Research "Production of a molecule for memory of salt concentration" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/production-of-a-molecule-for-memory-of-salt-concentration.html
本文を読む

https://repository.dl.itc.u-tokyo.ac.jp/?action=repository_action_common_download&item_id=735&item_no=1&attribute_id=19&file_no=1

このアイテムのアクセス数:  回

その他の情報