紀要論文 Pemphigus Vulgaris with Marked Stenosis of the Esophageal Orifice from an Osteoporosis Drug: a Case Study with Long-term Follow-up

Ishibashi, Takuya  ,  Hirakawa, Katsuhiro  ,  Takeno, Sachio  ,  Takumida, Masaya

66 ( 2 )  , pp.27 - 30 , 2017-08 , Hiroshima University Medical Press
ISSN:0018-2052
NII書誌ID(NCID):AA00664312
内容記述
Pemphigus vulgaris produces multiple and intractable erosions of the oral mucosa in the head and neck region. We describe a case of pemphigus vulgaris that showed erosions in the hypopharynx and stenosis of the esophageal orifice from an osteoporosis drug. A 73-year-old woman was admitted with oral intake difficulty and erosions in the hypopharynx. During the first admission, we could not make a definite diagnosis by biopsy or blood examination. The condition of the mucosa worsened subsequently; an esophagram showed marked stenosis of the esophageal orifice. As a possible factor exacerbating the stenosis, an osteoporosis drug was considered. The stenosis was improved by balloon expansion. One year after the first medical examination, we finally made a definite diagnosis of pemphigus vulgaris from the results of a blood examination in which anti-desmoglein 3 turned positive when the hypopharyngeal erosions and stenosis of the esophageal orifice became worse. Systemic treatment with a steroid was effective for the control of pemphigus vulgaris; restenosis of the esophageal orifice was recognized twice during a state of remission, and careful follow-up will be necessary in the future.
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http://ir.lib.hiroshima-u.ac.jp/files/public/4/44646/20180105105628457357/HiroshimaJMedSci_66_27.pdf

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