Departmental Bulletin Paper Russell Body Gastritis Concurrent with Eosinophilia: a case report

Imai, Takeharu  ,  Sentani, Kazuhiro  ,  Yamashita, Kazuomi  ,  Oue, Naohide  ,  Yoshida, Kazuhiro  ,  Yasui, Wataru

65 ( 3-4 )  , pp.69 - 72 , 2016-12 , Hiroshima University Medical Press
A 64-year-old male patient with a histological diagnosis of Russell body gastritis and with eosinophilic infiltrate in biopsy specimens is reported. The patient continued hemodialysis and pseudomembranous enteritis was contracted. Upper gastrointestinal endoscopy was performed due to poor appetite and blood eosinophilia. During endoscopy, a flare, swollen mucous membrane, and multiple verrucous erosions were noted in the gastric antrum. Biopsy and histopathological examination of gastric mucosa showed infiltration of plasma cells containing Russell bodies and eosinophils. Plasma cells containing Russell bodies were positive for CD138, immunoglobulin A (IgA) and kappa-light chain. Giemsa stained biopsy specimen revealed that the patient was negative for Helicobacter pylori. The patient was diagnosed with Russell body gastritis with eosinophilia. This is the first report of Russell body gastritis concurrent with eosinophilia. We discussed the possible correlation between the presence of plasma cells containing Russell bodies and gastric eosinophilia.

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