紀要論文 Solitary Cranial Langerhans Cell Histiocytosis : Two case reports

Karki, Prasanna  ,  Hirano, Hirofumi  ,  Yamahata, Hitoshi  ,  Fujio, Shingo  ,  Yonezawa, Hajime  ,  Iida, Koji  ,  Bohara, Manoj  ,  Oyoshi, Tatsuki  ,  Hanaya, Ryosuke  ,  Arita, Kazunori

64 ( 4 )  , pp.59 - 63 , 2015-12 , Hiroshima University Medical Press
ISSN:0018-2052
NII書誌ID(NCID):AA00664312
内容記述
Langerhans cell histiocytosis (LCH) is a proliferation of Langerhans cells intermixed with inflammatory cells, in particular eosinophils, that may manifest as a unisystem (unifocal or multifocal) or multisystem disease. We describe the clinical and histologic spectrum of LCH of the orbit and skull in our two cases. Both cases had unifocal erosive skull lesions with a history of trauma. Typical histologic features included numerous histiocytes with varying degrees of giant cell formation and scattered eosinophilic granulocytes. The presence of Langerhans cells was confirmed by CD1a and S100 immunohistochemistry. LCH has an excellent prognosis when treated with surgical resection, steroids and radiotherapy or chemotherapy. One of our patients is disease free at 7 year follow-up and one patient had regression of lesion on follow-up.
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http://ir.lib.hiroshima-u.ac.jp/files/public/3/39063/20160209135757476739/HiroshimaJMedSci_64_59.pdf

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