Journal Article Regulation of glucagon-like peptide-1 sensitivity by gut microbiota dysbiosis

Yamane, Shunsuke  ,  Inagaki, Nobuya

9 ( 2 )  , pp.262 - 264 , 2018-03-04 , Blackwell Publishing
Gut microbiota dysbiosis reduces expression of GLP‐1 receptor (GLP‐1R) and neuronal nitric oxide synthase (nNOS) in the enteric nervous system and hampers GLP‐1‐induced nitric oxide (NO) production through a pattern recognition receptor (PRR)‐dependent mechanism, hence preventing activation of the gut–brain–periphery axis for control of insulin secretion and gastric emptying.

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