学術雑誌論文 Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals

Goda, Tadahiro  ,  Doi, Masao  ,  Umezaki, Yujiro  ,  Murai, Iori  ,  Shimatani, Hiroyuki  ,  Chu, Michelle L.  ,  Nguyen, Victoria H.  ,  Okamura, Hitoshi  ,  Hamada, Fumika N.

32 ( 2 )  , pp.140 - 155 , 2018-01-15 , Cold Spring Harbor Laboratory
ISSN:0890-9369
内容記述
マウスとハエに共通にみられる体温の日内リズムを制御する仕組み. 京都大学プレスリリース. 2018-02-14.
Daily body temperature rhythm (BTR) is essential for maintaining homeostasis. BTR is regulated separately from locomotor activity rhythms, but its molecular basis is largely unknown. While mammals internally regulate BTR, ectotherms, including Drosophila, exhibit temperature preference rhythm (TPR) behavior to regulate BTR. Here, we demonstrate that the diuretic hormone 31 receptor (DH31R) mediates TPR during the active phase in Drosophila. DH31R is expressed in clock cells, and its ligand, DH31, acts on clock cells to regulate TPR during the active phase. Surprisingly, the mouse homolog of DH31R, calcitonin receptor (Calcr), is expressed in the suprachiasmatic nucleus (SCN) and mediates body temperature fluctuations during the active phase in mice. Importantly, DH31R and Calcr are not required for coordinating locomotor activity rhythms. Our results represent the first molecular evidence that BTR is regulated distinctly from locomotor activity rhythms and show that DH31R/Calcr is an ancient specific mediator of BTR during the active phase in organisms ranging from ectotherms to endotherms.
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http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/229398/1/gad.307884.117.pdf

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