Research Paper Translational control of mRNAs by 3'-Untranslated region binding proteins

Yamashita, Akio  ,  Takeuchi, Osamu

50 ( 4 )  , pp.194 - 200 , 2017-04-30 , Korean Society for Biochemistry and Molecular Biology - BMB Reports
Eukaryotic gene expression is precisely regulated at all points between transcription and translation. In this review, we focus on translational control mediated by the 3`-untranslated regions (UTRs) of mRNAs. mRNA 3`-UTRs contain cis-acting elements that function in the regulation of protein translation or mRNA decay. Each RNA binding protein that binds to these cis-acting elements regulates mRNA translation via various mechanisms targeting the mRNA cap structure, the eukaryotic initiation factor 4E (eIF4E)-eIF4G complex, ribosomes, and the poly (A) tail. We also discuss translation-mediated regulation of mRNA fate.

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