Departmental Bulletin Paper 前立腺全摘除術後に異好性抗体によるPSA偽高値を呈した1例
False Elevation of Prostate-Specific Antigen Caused by Heterophilic Antibody Interference after Radical Prostatectomy : A Case Report

上山, 裕樹  ,  宗宮, 伸弥  ,  藤川, 祥平  ,  山田, 祐也  ,  玉置, 雅弘  ,  金岡, 俊雄  ,  林, 正

63 ( 10 )  , pp.435 - 437 , 2017-10-31 , 泌尿器科紀要刊行会
We described a 63-year-old man who was diagnosed with clinical T1c prostate cancer, with a Gleason score of 6 (3+3), and a preoperative prostate-specific antigen (PSA) level of 5. 27 ng/ml. Radical prostatectomy(RP) was performed and final pathologyshowed Gleason score 3+4, pT2c with negative surgical margin. In spite of suggested surgical radicality, PSA was 3.32, 4.78, 5.93 ng/ml, at 1, 2, and 3 months after RP, respectively. However, radiological investigation revealed no metastasis. Because of this clinical discrepancy, we checked the PSA-α1-antichemotrypsin level and found it to be ≦0.1 ng/ml. From these results, false PSA elevation caused byinterference of positive heterophilic antibodies was suggested and demonstrated byseveral immunoassays.

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