学術雑誌論文 UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage–specific manner

Ishikawa, Tokiro  ,  Toyama, Takuya  ,  Nakamura, Yuki  ,  Tamada, Kentaro  ,  Shimizu, Hitomi  ,  Ninagawa, Satoshi  ,  Okada, Tetsuya  ,  Kamei, Yasuhiro  ,  Ishikawa-Fujiwara, Tomoko  ,  Todo, Takeshi  ,  Aoyama, Eriko  ,  Takigawa, Masaharu  ,  Harada, Akihiro  ,  Mori, Kazutoshi

216 ( 6 )  , pp.1761 - 1774 , 2017-06-05 , Rockefeller University Press
ISSN:0021-9525
内容記述
The unfolded protein response (UPR) handles unfolded/misfolded proteins accumulated in the endoplasmic reticulum (ER). However, it is unclear how vertebrates correctly use the total of ten UPR transducers. We have found that ER stress occurs physiologically during early embryonic development in medaka fish and that the smooth alignment of notochord cells requires ATF6 as a UPR transducer, which induces ER chaperones for folding of type VIII (short-chain) collagen. After secretion of hedgehog for tissue patterning, notochord cells differentiate into sheath cells, which synthesize type II collagen. In this study, we show that this vacuolization step requires both ATF6 and BBF2H7 as UPR transducers and that BBF2H7 regulates a complete set of genes (Sec23/24/13/31, Tango1, Sedlin, and KLHL12) essential for the enlargement of COPII vesicles to accommodate long-chain collagen for export, leading to the formation of the perinotochordal basement membrane. Thus, the most appropriate UPR transducer is activated to cope with the differing physiological ER stresses of different content types depending on developmental stage.
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http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/227005/1/jcb.201609100.pdf

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