学術雑誌論文 ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson's Disease

Nakano, Masaki  ,  Imamura, Hiromi  ,  Sasaoka, Norio  ,  Yamamoto, Masamichi  ,  Uemura, Norihito  ,  Shudo, Toshiyuki  ,  Fuchigami, Tomohiro  ,  Takahashi, Ryosuke  ,  Kakizuka, Akira

22pp.225 - 241 , 2017-08 , Elsevier B.V.
ISSN:2352-3964
内容記述
ATPを調整しパーキンソン病の進行を抑制、マウスで確認. 京都大学プレスリリース. 2017-08-31.
Parkinson's disease is assumed to be caused by mitochondrial dysfunction in the affected dopaminergic neurons in the brain. We have recently created small chemicals, KUSs (Kyoto University Substances), which can reduce cellular ATP consumption. By contrast, agonistic ligands of ERRs (estrogen receptor-related receptors) are expected to raise cellular ATP levels via enhancing ATP production. Here, we show that esculetin functions as an ERR agonist, and its addition to culture media enhances glycolysis and mitochondrial respiration, leading to elevated cellular ATP levels. Subsequently, we show the neuroprotective efficacies of KUSs, esculetin, and GSK4716 (an ERRγ agonist) against cell death in Parkinson's disease models. In the surviving neurons, ATP levels and expression levels of α-synuclein and CHOP (an ER stress-mediated cell death executor) were all rectified. We propose that maintenance of ATP levels, by inhibiting ATP consumption or enhancing ATP production, or both, would be a promising therapeutic strategy for Parkinson's disease.
本文を読む

http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/226936/1/j.ebiom.2017.07.024.pdf

このアイテムのアクセス数:  回

その他の情報