学術雑誌論文 Office-based simple frailty score and central blood pressure predict mild cognitive impairment in an apparently healthy Japanese population: J-SHIPP study

Ohara, Maya  ,  Kohara, Katsuhiko  ,  Okada, Yoko  ,  Ochi, Masayuki  ,  Nagai, Tokihisa  ,  Ohyagi, Yasumasa  ,  Tabara, Yasuharu  ,  Igase, Michiya

72017-4-13 , Springer Nature
ISSN:2045-2322
内容記述
railty is associated with cognitive impairment and can be used to identify people at high risk for dementia. We developed a simple frailty (SF) score using a combination of low hand grip strength (<32.5 kg in men, <19.5 kg in women), and short one-leg standing time (<20 seconds). These can be easily measured in the clinician’s office when seeing patients. We investigated the possible association between SF score and mild cognitive impairment (MCI) in a cross-sectional study with 838 independent middle-aged to elderly participants (319 men, mean age 65.1years). In total, 118 participants were diagnosed with MCI. A SF score of 2 was significantly associated with the presence of MCI (odds ratio 4.6, 95% confidence interval: 1.9–6.9, p = 0.0001) even after adjustment for age and sex. Stepwise regression analyses showed that a SF score of 2 was associated with the presence of MCI, independently of central pulse pressure and silent cerebral infarcts. These findings indicate that the SF score is a useful frailty parameter to predict MCI in an apparently independent population.
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http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/225250/1/srep46419.pdf

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