学術雑誌論文 Sphingosine kinase 1-interacting protein is a novel regulator of glucose-stimulated insulin secretion

Wang, Yu  ,  Harashima, Shin Ichi  ,  Liu, Yanyan  ,  Usui, Ryota  ,  Inagaki, Nobuya

72017-04-10 , Springer Nature
ISSN:2045-2322
内容記述
Glucose-stimulated insulin secretion (GSIS) is essential in keeping blood glucose levels within normal range. GSIS is impaired in type 2 diabetes, and its recovery is crucial in treatment of the disease. We find here that sphingosine kinase 1-interacting protein (SKIP, also called Sphkap) is highly expressed in pancreatic β-cells but not in α-cells. Intraperitoneal glucose tolerance test showed that plasma glucose levels were decreased and insulin levels were increased in SKIP-/- mice compared to SKIP+/+ mice, but exendin-4-enhanced insulin secretion was masked. GSIS was amplified more in SKIP-/- but exendin-4-enhanced insulin secretion was masked compared to that in SKIP+/+ islets. The ATP and cAMP content were similarly increased in SKIP+/+ and SKIP-/- islets; depolarization-evoked, PKA and cAMP-mediated insulin secretion were not affected. Inhibition of PDE activity equally augmented GSIS in SKIP+/+ and SKIP-/- islets. These results indicate that SKIP modulates GSIS by a pathway distinct from that of cAMP-, PDE- A nd sphingosine kinase-dependent pathways.
本文を読む

http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/225105/1/s41598-017-00900-7.pdf

このアイテムのアクセス数:  回

その他の情報