学術雑誌論文 Clinical significance of soluble CD163 in polymyositis-related or dermatomyositis-related interstitial lung disease

Enomoto, Yasunori  ,  Suzuki, Yuzo  ,  Hozumi, Hironao  ,  Mori, Kazutaka  ,  Kono, Masato  ,  Karayama, Masato  ,  Furuhashi, Kazuki  ,  Fujisawa, Tomoyuki  ,  Enomoto, Noriyuki  ,  Nakamura, Yutaro  ,  Inui, Naoki  ,  Suzuki, Daisuke  ,  Ogawa, Noriyoshi  ,  Nakashima, Ran  ,  Mimori, Tsuneyo  ,  Iwashita, Toshihide  ,  Suda, Takafumi

192017-01-19 , BioMed Central Ltd.
ISSN:1478-6362
内容記述
Background: Macrophage activation is involved in the pathogenesis of polymyositis (PM)/dermatomyositis (DM). CD163, a scavenger receptor expressed on the surface of activated macrophages, mediates anti-inflammatory functions. This study aimed to evaluate the clinical significance of soluble CD163 (sCD163) in PM/DM-related interstitial lung disease (ILD). Methods: The main subjects were 48 patients with PM/DM-related ILD. As controls, 10 patients with PM/DM without ILD and 20 healthy volunteers were enrolled. In patients with PM/DM-related ILD, the baseline characteristics and clinical course were obtained through a review of patient medical records. Serum sCD163 levels at ILD diagnosis were quantified by enzyme-linked immunosorbent assay, which were compared with the other baseline clinical factors and evaluated for potential as a prognostic biomarker. In addition, immunohistochemistry analysis using anti-human CD163 antibody was performed on the lung sections of two patients with DM-related ILD (a survivor and non-survivor, respectively) and one patient with early-stage lung cancer as a normal control. Results: The median value of serum sCD163 in patients with PM/DM-related ILD was 818 ng/mL, which was higher than that of PM/DM patients without ILD and healthy volunteers (716 ng/mL and 340 ng/mL, respectively). Significant but mild correlations with serum sCD163 levels were observed for serum C-reactive protein levels (r = 0.322) and % predicted forced vital capacity (r = -0.301) in patients with PM/DM-related ILD. A Cox proportional hazard model demonstrated that patients with PM/DM-related ILD and higher sCD163 levels had worse prognosis (age-adjusted and gender-adjusted hazard ratio per 100 ng/mL increase 1.27, 95% confidence interval 1.11-1.45, P <0.001). In immunohistochemistry analysis, compared with normal lung, alveolar infiltration of CD163-positive macrophages was evident in the lungs of patients with DM-related ILD. Especially, the finding was more severe in the non-survivor's lung. Conclusions: Serum sCD163 might be a potential biomarker for predicting the severity and prognosis of PM/DM-related ILD. Our results suggest the importance of macrophage activation in the disease.
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http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/218306/1/s13075-016-1214-8.pdf

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