学術雑誌論文 Morphogenesis of the Inner Ear at Different Stages of Normal Human Development

Toyoda, Saki  ,  Shiraki, Naoto  ,  Yamada, Shigehito  ,  Uwabe, Chigako  ,  Imai, Hirohiko  ,  Matsuda, Tetsuya  ,  Yoneyama, Akio  ,  Takeda, Tohoru  ,  Takakuwa, Tetsuya

298 ( 12 )  , pp.2081 - 2090 , 2015-12 , Blackwell Publishing Inc.
ISSN:1932-8494
内容記述
This study examined the external morphology and morphometry of the human embryonic inner ear membranous labyrinth and documented its three-dimensional position in the developing embryo using phase-contrast X-ray computed tomography and magnetic resonance imaging. A total of 27 samples between Carnegie stage (CS) 17 and the postembryonic phase during trimester 1 (approximately 6-10 weeks after fertilization) were included. The otic vesicle elongated along the dorso-ventral axis and differentiated into the end lymphatic appendage and cochlear duct (CD) at CS 17. The spiral course of the CD began at CS18, with anterior and posterior semicircular ducts (SDs) forming prominent circles with a common crus. The spiral course of the CD comprised more than two turns at the postembryonic phase, at which time the height of the CD was evident. A linear increase was observed in the length of anterior, posterior, and lateral SDs, in that order, and the length of the CD increased exponentially over the course of development. Bending in the medial direction was observed between the cochlear and vestibular parts from the latero-caudal view, with the angle decreasing during development. The position of the inner ear was stable throughout the period of observation on the lateral to ventral side of the rhombencephalon, caudal to the pontine flexure, and adjacent to the auditory ganglia. The plane of the lateral semicircular canal was approximately 8.0°-14.6° with respect to the cranial caudal (z-)axis, indicating that the orientation of the inner ear changes during growth to adulthood.
本文を読む

http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/216673/1/ar.23268.pdf

このアイテムのアクセス数:  回

その他の情報