Journal Article Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model

Yamamoto, Mako  ,  Zhao, Ming  ,  Hiroshima, Yukihiko  ,  Zhang, Yong  ,  Shurell, Elizabeth  ,  Eilber, Fritz C.  ,  Bouvet, Michael  ,  Noda, Makoto  ,  Hoffman, Robert M.

11 ( 8 ) 2016-08-08 , Public Library of Science
Tumor-targeting Salmonella enterica serovar Typhimurium A1-R (Salmonella A1-R) had strong efficacy on a melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. GFP-expressing Salmonella A1-R highly and selectively colonized the PDOX melanoma and significantly suppressed tumor growth (p = 0. 021). The combination of Salmonella A1-R and cisplatinum (CDDP), both at low-dose, also significantly suppressed the growth of the melanoma PDOX (P = 0. 001). Salmonella A1-R has future clinical potential for combination chemotherapy with CDDP of melanoma, a highly-recalcitrant cancer.

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