Journal Article <論文・報告>海洋放線菌由来のヘロナミドC からのヘロナミドA およびB の生成と抗真菌活性

山前, 結  ,  藤田, 航平  ,  西村, 慎一  ,  掛谷, 秀昭

1pp.63 - 65 , 2016-03 , 京都大学学際融合教育研究推進センター高大接続科学教育ユニット
Heronamide C is a 20-membered polyene macrolactam isolated from a marine-derived Streptomyces sp. and shows potent antifungal activity by targeting membrane phospholipids. Testing the stability of heronamide C under UV irradiation (365 nm) revealed that heronamide C is converted mainly to heronamide B and a minor product, heronamide A, as determined by LC-MS analysis. In addition, the antifungal activity of heronamides A and B as tested against fission yeast was much weaker than that of heronamide C. Taking these results together, further structure-activity relationship studies of the heronamides are helpful for developing a chemical probe and a promising lead compound for antifungal drugs. Keywords: Heronamides, Polyene, Macrolactam, a Marine-derived Streptomyces, Antifungal activity, Liquid chromatography-mass spectrometry, Natural product chemistry, Chemical probe, Chemical biology

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