学術雑誌論文 Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.

Shiraishi, Kouya  ,  Okada, Yukinori  ,  Takahashi, Atsushi  ,  Kamatani, Yoichiro  ,  Momozawa, Yukihide  ,  Ashikawa, Kyota  ,  Kunitoh, Hideo  ,  Matsumoto, Shingo  ,  Takano, Atsushi  ,  Shimizu, Kimihiro  ,  Goto, Akiteru  ,  Tsuta, Koji  ,  Watanabe, Shun-Ichi  ,  Ohe, Yuichiro  ,  Watanabe, Yukio  ,  Goto, Yasushi  ,  Nokihara, Hiroshi  ,  Furuta, Koh  ,  Yoshida, Akihiko  ,  Goto, Koichi  ,  Hishida, Tomoyuki  ,  Tsuboi, Masahiro  ,  Tsuchihara, Katsuya  ,  Miyagi, Yohei  ,  Nakayama, Haruhiko  ,  Yokose, Tomoyuki  ,  Tanaka, Kazumi  ,  Nagashima, Toshiteru  ,  Ohtaki, Yoichi  ,  Maeda, Daichi  ,  Imai, Kazuhiro  ,  Minamiya, Yoshihiro  ,  Sakamoto, Hiromi  ,  Saito, Akira  ,  Shimada, Yoko  ,  Sunami, Kuniko  ,  Saito, Motonobu  ,  Inazawa, Johji  ,  Nakamura, Yusuke  ,  Yoshida, Teruhiko  ,  Yokota, Jun  ,  Matsuda, Fumihiko  ,  Matsuo, Keitaro  ,  Daigo, Yataro  ,  Kubo, Michiaki  ,  Kohno, Takashi

72016-08-09 , Springer Nature
ISSN:2041-1723
内容記述
日本人に多いEGFR変異を持つ肺腺がんの罹りやすさを決める遺伝子領域発見-免疫を司るHLA遺伝子など6遺伝子領域が関与-. 京都大学プレスリリース. 2016-08-25.
Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30-50%) than in European/Americans (10-20%). Here we investigate genetic factors underlying the risk of this disease by conducting a genome-wide association study, followed by two validation studies, in 3,173 Japanese patients with EGFR mutation-positive lung adenocarcinoma and 15,158 controls. Four loci, 5p15.33 (TERT), 6p21.3 (BTNL2), 3q28 (TP63) and 17q24.2 (BPTF), previously shown to be strongly associated with overall lung adenocarcinoma risk in East Asians, were re-discovered as loci associated with a higher susceptibility to EGFR mutation-positive lung adenocarcinoma. In addition, two additional loci, HLA class II at 6p21.32 (rs2179920; P =5.1 × 10(-17), per-allele OR=1.36) and 6p21.1 (FOXP4) (rs2495239; P=3.9 × 10(-9), per-allele OR=1.19) were newly identified as loci associated with EGFR mutation-positive lung adenocarcinoma. This study indicates that multiple genetic factors underlie the risk of lung adenocarcinomas with EGFR mutations.
本文を読む

http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/216381/1/ncomms12451.pdf

このアイテムのアクセス数:  回

その他の情報