|
Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effectsSingle ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects |
"/Hashidume, Tsutomu/"Hashidume, Tsutomu ,
"/Kato, Asuka/"Kato, Asuka ,
"/Tanaka, Tomohiro/"Tanaka, Tomohiro ,
"/Miyoshi, Shoko/"Miyoshi, Shoko ,
"/Itoh, Nobuyuki/"Itoh, Nobuyuki ,
"/Nakata, Rieko/"Nakata, Rieko ,
"/Inoue, Hiroyasu/"Inoue, Hiroyasu ,
"/Oikawa, Akira/"Oikawa, Akira ,
"/Nakai, Yuji/"Nakai, Yuji ,
"/Shimizu, Makoto/"Shimizu, Makoto ,
"/Inoue, Jun/"Inoue, Jun ,
"/Sato, Ryuichiro/"Sato, Ryuichiro
62016-06-17 , Nature Publishing Group
ISSN:2045-2322
Description
Soy protein β-conglycinin has serum lipid-lowering and anti-obesity effects. We showed that single ingestion of β-conglycinin after fasting alters gene expression in mouse liver. A sharp increase in fibroblast growth factor 21 (FGF21) gene expression, which is depressed by normal feeding, resulted in increased postprandial circulating FGF21 levels along with a significant decrease in adipose tissue weights. Most increases in gene expressions, including FGF21, were targets for the activating transcription factor 4 (ATF4), but not for peroxisome proliferator-activated receptor α. Overexpression of a dominant-negative form of ATF4 significantly reduced β-conglycinin-induced increases in hepatic FGF21 gene expression. In FGF21-deficient mice, β-conglycinin effects were partially abolished. Methionine supplementation to the diet or primary hepatocyte culture medium demonstrated its importance for activating liver or hepatocyte ATF4-FGF21 signaling. Thus, dietary β-conglycinin intake can impact hepatic and systemic metabolism by increasing the postprandial circulating FGF21 levels.
Full-Text
http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/215758/1/srep28183.pdf
