Journal Article Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects

Hashidume, Tsutomu  ,  Kato, Asuka  ,  Tanaka, Tomohiro  ,  Miyoshi, Shoko  ,  Itoh, Nobuyuki  ,  Nakata, Rieko  ,  Inoue, Hiroyasu  ,  Oikawa, Akira  ,  Nakai, Yuji  ,  Shimizu, Makoto  ,  Inoue, Jun  ,  Sato, Ryuichiro

62016-06-17 , Nature Publishing Group
Soy protein β-conglycinin has serum lipid-lowering and anti-obesity effects. We showed that single ingestion of β-conglycinin after fasting alters gene expression in mouse liver. A sharp increase in fibroblast growth factor 21 (FGF21) gene expression, which is depressed by normal feeding, resulted in increased postprandial circulating FGF21 levels along with a significant decrease in adipose tissue weights. Most increases in gene expressions, including FGF21, were targets for the activating transcription factor 4 (ATF4), but not for peroxisome proliferator-activated receptor α. Overexpression of a dominant-negative form of ATF4 significantly reduced β-conglycinin-induced increases in hepatic FGF21 gene expression. In FGF21-deficient mice, β-conglycinin effects were partially abolished. Methionine supplementation to the diet or primary hepatocyte culture medium demonstrated its importance for activating liver or hepatocyte ATF4-FGF21 signaling. Thus, dietary β-conglycinin intake can impact hepatic and systemic metabolism by increasing the postprandial circulating FGF21 levels.

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