Journal Article Pandemic HIV-1 Vpu overcomes intrinsic herd immunity mediated by tetherin

Iwami, Shingo  ,  Sato, Kei  ,  Morita, Satoru  ,  Inaba, Hisashi  ,  Kobayashi, Tomoko  ,  Takeuchi, Junko S.  ,  Kimura, Yuichi  ,  Misawa, Naoko  ,  Ren, Fengrong  ,  Iwasa, Yoh  ,  Aihara, Kazuyuki  ,  Koyanagi, Yoshio

52015-07-17 , Nature Publishing Group
Among the four groups of HIV-1 (M ,N, O, and P), HIV-1M alone is pandemic and has rapidly expanded across the world. However, why HIV-1M has caused a devastating pandemic while the other groups remain contained is unclear. Interestingly, only HIV-1M Vpu, a viral protein, can robustly counteract human tetherin, which tethers budding virions. Therefore, we hypothesize that this property of HIV-1M Vpu facilitates human-to-human viral transmission. Adopting a multilayered experimental-mathematical approach, we demonstrate that HIV-1M Vpu confers a 2.38-fold increase in the prevalence of HIV-1 transmission. When Vpu activity is lost, protected human populations emerge (i.e., intrinsic herd immunity develops) through the anti-viral effect of tetherin. We also reveal that all Vpus of transmitted/founder HIV-1M viruses maintain anti-tetherin activity. These findings indicate that tetherin plays the role of a host restriction factor, providing 'intrinsic herd immunity', whereas Vpu has evolved in HIV-1M as a tetherin antagonist.

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