学術雑誌論文 Resectable hepatoblastoma with tumor thrombus extending into the right atrium after chemotherapy: A case report

Endo, Kosuke  ,  Yokoi, Akiko  ,  Mishima, Yasuhiko  ,  Tamaki, Akihiko  ,  Takemoto, Junkichi  ,  Morita, Keiichi  ,  Iwade, Tamaki  ,  Okata, Yuichi  ,  Fukuzawa, Hiroaki  ,  Bitoh, Yuko  ,  Hasegawa, Tomomi  ,  Yoshida, Makiko  ,  Akasaka, Yoshinobu  ,  Okajima, Hideaki  ,  Oshima, Yoshihiro  ,  Maeda, Kosaku  ,  Uemoto, Shinji

7pp.20 - 22 , 2016-04 , Elsevier Inc.
ISSN:2213-5766
内容記述
Hepatoblastoma with intraatrial tumor thrombus is relatively rare. We report a case of hepatoblastoma with tumor thrombus extending into the right atrium, which responded well to chemotherapy and was resected using extracorporeal circulation. A 4-year-old girl was referred to our hospital because of abdominal distention and tenderness. A computed tomography (CT) scan showed a large tumor occupying the left 3 segments of the liver with tumor thrombus extending into the right atrium. There was also a small intrahepatic metastasis in the right lobe of the liver. She was diagnosed with hepatoblastoma on the basis of the results of open biopsy. Neoadjuvant chemotherapy with an intense CDDP-based regimen was performed. The tumor responded well to chemotherapy, and intrahepatic metastasis became undetectable on CT scan, although the tumor thrombus remained in the right atrium. After 7 courses of chemotherapy, we performed resection using extracorporeal circulation. The postoperative course was uneventful, and adjuvant chemotherapy was started 10 days after the operation. Her serum alpha-fetoprotein (AFP) level decreased to the normal range, and she was free of disease for 1 year after the operation. Tumor resection using extracorporeal circulation can be performed safely and is justified in patients with intraatrial tumor thrombus.
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http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/215116/1/j.epsc.2016.01.004.pdf

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