Journal Article Radial fundus autofluorescence in the periphery in patients with X-linked retinitis pigmentosa

Ogino, Ken  ,  Oishi, Maho  ,  Oishi, Akio  ,  Morooka, Satoshi  ,  Sugahara, Masako  ,  Gotoh, Norimoto  ,  Kurimoto, Masafumi  ,  Yoshimura, Nagahisa

9pp.1467 - 1474 , 2015-08-17 , Dove Medical Press Ltd
Purpose: To describe the peripheral autofluorescence images and clinical features of patients with retinal dystrophy who showed radial fundus autofluorescence (FAF) at the posterior pole. Methods: The authors retrospectively reviewed pooled wide-field FAF images of 711 patients with retinal dystrophy and 56 family members. Results: Eleven eyes of seven women exhibited radial FAF at the posterior pole. Wide-field FAF showed extension of the radial pattern to the periphery in all eyes except one. One woman showed radial hyper-FAF only in the periphery, not at the posterior pole. These eight individuals were X-linked retinitis pigmentosa patients or carriers. The tapetal-like reflex was not observed in their color fundus photographs. The peripheral visual field showed wedge-shaped restriction in some individuals. Conclusion: Wide-field FAF imaging can depict radial FAF not only at the posterior pole but also in the periphery in X-linked retinitis pigmentosa carriers. The authors therefore agree with previous reports that radial FAF may be a hallmark of X-linked retinitis pigmentosa.

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