Journal Article Fish oil accelerates diet-induced entrainment of the mouse peripheral clock via GPR120

Furutani, Akiko  ,  Ikeda, Yuko  ,  Itokawa, Misa  ,  Nagahama, Hiroki  ,  Ohtsu, Teiji  ,  Furutani, Naoki  ,  Kamagata, Mayo  ,  Yang, Zhi Hong  ,  Hirasawa, Akira  ,  Tahara, Yu  ,  Shibata, Shigenobu

10 ( 7 ) 2015-07-10 , Public Library of Science
The circadian peripheral clock is entrained by restricted feeding (RF) at a fixed time of day, and insulin secretion regulates RF-induced entrainment of the peripheral clock in mice. Thus, carbohydrate-rich food may be ideal for facilitating RF-induced entrainment, although the role of dietary oils in insulin secretion and RF-induced entrainment has not been described. The soybean oil component of standard mouse chow was substituted with fish or soybean oil containing docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA). Tuna oil (high DHA/EPA), menhaden oil (standard), and DHA/EPA dissolved in soybean oil increased insulin secretion and facilitated RF-induced phase shifts of the liver clock as represented by the bioluminescence rhythms of PER2::LUCIFERASE knock-in mice. In this model, insulin depletion blocked the effect of tuna oil and fish oil had no effect on mice deficient for GPR120, a polyunsaturated fatty acid receptor. These results suggest food containing fish oil or DHA/EPA is ideal for adjusting the peripheral clock.

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