学術雑誌論文 Hemostasis management of tooth extraction in a patient with Bernard–Soulier syndrome and a severe bleeding tendency: A case report

Mishima, Sayaka  ,  Nakao, Kazumasa  ,  Ikeno, Masayuki  ,  Bessho, Kazuhisa

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
27 ( 4 )  , pp.525 - 528 , 2015-07 , Elsevier Japan KK
ISSN:2212-5558
内容記述
Bernard–Soulier syndrome is characterized by thrombocytopenia, giant platelets, and severe bleeding; although bleeding varies widely, it is usually evident from childhood and requires particular attention during surgeries. We extracted a fractured tooth and performed hemostasis management in a male patient with a Bernard–Soulier syndrome-related severe bleeding tendency after intracerebral hemorrhage. The preoperative platelet count was abnormally low (7 × 10[9]/L). Normal coagulability was observed. After intravenous hydrocortisone administration, he received 10 human leukocyte antigen-matched platelet units. The extraction sites were packed with gelatine sponges and a splint was used for hemostasis. Excellent hemostasis was achieved with minimal human leukocyte antigen-matched platelets.
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http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/207519/1/j.ajoms.2014.09.010.pdf

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