Journal Article High-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: a report from the CREDO-Kyoto registry cohort-2.

Izuhara, Masayasu  ,  Ono, Koh  ,  Shiomi, Hiroki  ,  Morimoto, Takeshi  ,  Furukawa, Yutaka  ,  Nakagawa, Yoshihisa  ,  Shizuta, Satoshi  ,  Tada, Tomohisa  ,  Tazaki, Junichi  ,  Horie, Takahiro  ,  Kuwabara, Yasuhide  ,  Baba, Osamu  ,  Nishino, Tomohiro  ,  Kita, Toru  ,  Kimura, Takeshi

242 ( 2 )  , pp.632 - 638 , 2015-10 , Elsevier Ltd.
[Objective]To determine whether low HDL-C is a risk factor for adverse cardiovascular events in patients with known CAD. [Methods]We evaluated 10, 391 patients who underwent PCI from January 2005 to December 2007. In total, 3838 (36.9%) patients had low HDL-C (HDL-C <40 mg/dL in males and <50 mg/dL in females) and 6553 (63.1%) patients had normal HDL-C based on measurements on admission. [Results]The unadjusted 5-year incidence of major adverse cardiac events (MACE: composite of cardiovascular death, myocardial infarction or stroke) was significantly higher in the low HDL-C group than in the normal HDL-C group (17.6% vs. 14.0%, P < 0.0001). However, after adjusting for confounders, low HDL-C was not associated with a higher risk of MACE (adjusted hazard ratio [HR] 1.07, 95% confidence interval (CI) 0.97?1.19; P = 0.19). There was no significant interaction between the effect of low HDL-C on MACE and several subgroup factors including age, sex, clinical presentation of CAD, statins use, serum low-density lipoprotein cholesterol level, and serum triglycerides level. [Conclusion]Low HDL-C, as compared with normal HDL-C, was not associated with higher 5-year risk of MACE in patients who underwent PCI.

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