Journal Article Synthesis and functional evaluation of chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups as highly sensitive MRI contrast agents

Miyake, Yuka  ,  Kimura, Yu  ,  Orito, Naomi  ,  Imai, Hirohiko  ,  Matsuda, Tetsuya  ,  Toshimitsu, Akio  ,  Kondo, Teruyuki

71 ( 26-27 )  , pp.4438 - 4444 , 2015-07-01 , Elsevier Ltd.
ISSN:0040-4020
NCID:AA00861787
Description
Novel chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups were synthesized and shown to have longitudinal relaxivity (r1) values 5 times higher than that of clinically used Gd-DTPA. The affinities of Gd-4a and Gd-4b for bovine serum albumin (BSA), respectively, were estimated by a quartz crystal microbalance (QCM) measurement. The amino groups of the dendrimer were then conjugated with PEG. This conjugation with PEG strongly affected its ability to attenuate signals in T1-weighted MRI.
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http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/201952/1/j.tet.2015.04.050.pdf

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