||Small molecule binding to a G-hairpin and a G-triplex: a new insight into anticancer drug design targeting G-rich regions.
Rajendran, Arivazhagan ,
Endo, Masayuki ,
Hidaka, Kumi ,
Teulade-Fichou, Marie-Paule ,
Mergny, Jean-LouisSugiyama, Hiroshi
9184 , 2015-04-13 , Royal Society of Chemistry
To gain new insights into G-quadruplex-drug interactions, we captured the solution-state structures of the complexes between a drug-like small molecule and a G-hairpin/G-triplex. Our results indicated that the ligand initially binds to the intermediates and induces stepwise folding into a quadruplex.