学術雑誌論文 Small molecule binding to a G-hairpin and a G-triplex: a new insight into anticancer drug design targeting G-rich regions.

Rajendran, Arivazhagan  ,  Endo, Masayuki  ,  Hidaka, Kumi  ,  Teulade-Fichou, Marie-Paule  ,  Mergny, Jean-Louis  ,  Sugiyama, Hiroshi

51 ( 44 )  , pp.9181 - 9184 , 2015-04-13 , Royal Society of Chemistry
ISSN:1359-7345
NII書誌ID(NCID):AA11071130
内容記述
To gain new insights into G-quadruplex-drug interactions, we captured the solution-state structures of the complexes between a drug-like small molecule and a G-hairpin/G-triplex. Our results indicated that the ligand initially binds to the intermediates and induces stepwise folding into a quadruplex.
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http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/201620/1/c5cc01678a.pdf

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