||A chiral phosphoric acid catalyst for asymmetric construction of 1,3-dioxanes.
Matsumoto, Akira ,
Asano, KeisukeMatsubara, Seijiro
11696 , 2015-06-12 , Royal Society of Chemistry
Accepted 09 Jun 2015
A novel method of enantioselective 1, 3-dioxane construction via a hemiacetalization/intramolecular oxy-Michael addition cascade by a chiral phosphoric acid catalyst was developed. The product was successfully transformed into an optically active 1, 3-polyol motif, indicating that the proposed reaction can provide useful chiral building blocks for the de novo synthesis of polyketides.