Journal Article A chiral phosphoric acid catalyst for asymmetric construction of 1,3-dioxanes.

Matsumoto, Akira  ,  Asano, Keisuke  ,  Matsubara, Seijiro

51 ( 58 )  , pp.11693 - 11696 , 2015-06-12 , Royal Society of Chemistry
ISSN:1359-7345
NCID:AA11071130
Description
Accepted 09 Jun 2015
A novel method of enantioselective 1, 3-dioxane construction via a hemiacetalization/intramolecular oxy-Michael addition cascade by a chiral phosphoric acid catalyst was developed. The product was successfully transformed into an optically active 1, 3-polyol motif, indicating that the proposed reaction can provide useful chiral building blocks for the de novo synthesis of polyketides.
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