||Organocatalytic Activation of the Leaving Group in the Intramolecular Asymmetric S(N) 2' Reaction.
Kuroda, Yusuke ,
Harada, Shingo ,
Oonishi, Akinori ,
Yamaoka, Yousuke ,
Yamada, Ken-IchiTakasu, Kiyosei
8266 , 2015-05-28 , wiley
A Brønsted-acid-catalyzed intramolecular enantioselective S(N)2' reaction was developed utilizing trichloroacetimidate as a leaving group. The findings indicated that dual activation of the substrates is operative. This metal-free allylic alkylation allows highly enantioselective access to 2-vinylpyrrolidines bearing various substituents.